What is the role of tobramycin in the treatment of mycobacterium chelonae infection?

Updated: Dec 20, 2018
  • Author: Alfred Scott Lea, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Various antimicrobials, parenteral and oral, are summarized below that can be used in treatment of M chelonae infection if susceptible. In contrast to other NTM, tobramycin remains the aminoglycoside of choice compared with amikacin for M chelonae. [25, 29] Imipenem is the carbapenem of choice for treatment. M chelonae is universally resistant to cefoxitin in vitro. Approximately 20% of M chelonae isolates have a susceptible MIC to doxycycline. [29] Tigecycline has been shown to have good in vitro activity against M chelonae, but it does not have an established breakpoint and is usually considered when other alternatives are exhausted. [43, 44]


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