What is the WHO case definition of Chikungunya virus infection?

Updated: Aug 01, 2019
  • Author: Suganthini Krishnan Natesan, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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The case definition of Chikungunya fever as proposed by the World Health Organization (WHO) Regional Office for Southeast Asia is discussed below. [93]

Suspected case

A suspected case involves a patient presenting with acute onset of fever, usually with chills/rigors, that lasts for 3-5 days with pain in multiple joints/swelling of extremities that may continue for weeks to months.

Probable case

A probable case is characterized by conditions that support a suspected case (see above) along with one of the following conditions:

  • History of travel or residence in areas reporting outbreaks

  • Ability to exclude malaria, dengue, and any other known cause of fever with joint pains

Confirmed case

Chikungunya fever is confirmed in the patient meets one or more of the following findings irrespective of the clinical presentation:

  • Virus isolation in cell culture or animal inoculations from acute-phase sera (see also Workup)

  • Presence of viral ribonucleic acid (RNA) in acute-phase sera as determined with RT-PCR (see also Workup)

  • Presence of virus-specific IgM antibodies in single serum sample in acute phase or 4-fold increase in virus-specific IgG antibody titer in samples collected at least 3 weeks apart (see also Workup)

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