Which medications in the drug class Antifungal agents, Polyene are used in the treatment of Mucormycosis (Zygomycosis)?

Updated: Jul 06, 2021
  • Author: Avnish Sandhu, DO; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Antifungal agents, Polyene

These agents bind irreversibly to ergosterol within the fungal cell membrane. This binding results in disruption of membrane integrity, leakage of intracellular components, and, ultimately, cell death.

Liposomal amphotericin B (AmBisome)

Consists of a mixture of phosphatidylcholine, cholesterol, and distearoyl phosphatidylglycerol that arrange into amphotericin B–containing unilamellar vesicles in aqueous media. First-line therapy for mucormycosis at 5 mg/kg/d. Owing to decreased risk of nephrotoxicity at this dose, it can be used in the setting of preexisting renal dysfunction and when nephrotoxicity develops during amphotericin B deoxycholate therapy. Careful electrolyte monitoring and replacement is required.

Amphotericin B lipid complex (Abelcet)

Amphotericin B lipid complex is amphotericin B in phospholipid complexed form. This is an alternate therapy to liposomal amphotericin B.

Amphotericin B deoxycholate

Less commonly used than the lipid formulations because of higher rates of nephrotoxicity but less costly and more widely available. The typical dose is 1-1.5 mg/kg/d. The total dose given over the course of therapy is usually 2.5-3 g.


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