How is mucormycosis (zygomycosis) treated?

Updated: Jul 06, 2021
  • Author: Avnish Sandhu, DO; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Correction of the underlying abnormality, prompt initiation of liposomal amphotericin B therapy, and surgical resection are critical. [1, 72, 76]

Other important considerations in medical management include the following:

  • Diabetic ketoacidosis requires insulin and volume repletion with intravenous fluids.
  • Neutropenia is associated with hematologic malignancy and it should be reversed, if possible, with the use of colony-stimulating factors and the withdrawal of cytotoxic chemotherapy.
  • Wean off glucocorticosteroids and other immunosuppressive drugs.
  • Interrupt  deferoxamine therapy; hydroxypyridine chelating agents may be substituted for deferoxamine

The use of contaminated bandages and other dressings has caused cutaneous mucormycosis. Failure to examine areas under dressings or to recognize the significance of deterioration in preexisting wounds may produce severe cutaneous and, ultimately, disseminated disease. Placing patients with severe prolonged neutropenia in rooms equipped with high-efficiency particulate air (HEPA) filters, when feasible, may be beneficial.


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