What is the prognosis of mucormycosis (zygomycosis)?

Updated: Jul 06, 2021
  • Author: Avnish Sandhu, DO; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Prognosis and survival depend on early diagnosis and timely initiation of treatment. [38]  Mortality of mucormycosis varies between 40%-80%, despite advances in treatment; mortality depends on the site of infection. [39] Higher mortality of 80% is seen in among patients with disseminated disease to CNS [39] ; rhino-orbital-cereberal mucormycosis has a mortality rate of 25% to 62%. Among patients with orbital involvement, early diagnosis through nasal endoscopic examination and rapid initiation of treatment are important in improving disease specific mortality. [13, 40, 41, 42]  Rapid diagnosis, and early surgical debridement, lead to lower mortality; this can be achieved among patients with localized sinus and skin disease. [39, 43, 44]

Mortality is also high among patients with gastrointestinal manifestations, as diagnosis is often achieved late due to non-specific presentation. [39, 45]  Pulmonary mucormycosis carries a mortality rate of 57.1%, however mortality has improved over time due to combination of medical and surgical treatment. [46]

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