Which antibodies does an Epstein-Barr virus (EBV) mononucleosis (mono) infection induce?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Epstein-Barr virus (EBV) infection induces specific antibodies to EBV and various unrelated non-EBV heterophile antibodies. These heterophile antibodies react to antigens from animal RBCs.

  • Sheep RBCs agglutinate in the presence of heterophile antibodies and are the basis for the Paul-Bunnell test.

  • Agglutination of horse RBCs on exposure to heterophile antibodies is the basis of the Monospot test.

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