How is fatigue characterized in Epstein-Barr virus (EBV) infectious mononucleosis (mono) and what does chronic fatigue suggest?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Many infectious agents, including EBV infectious mononucleosis, are known to initiate a state of chronic fatigue. Appreciate that EBV may trigger chronic fatigue, but it does not cause chronic fatigue. The fatigue of EBV infection usually resolves within 3 months and uncommonly lasts for longer than 6 months. Patients with CFS have otherwise unexplained fatigue for a duration equal to or greater than 1 year (for a full discussion on CFS, see Chronic Fatigue Syndrome). In summary, acute, but not chronic, fatigue is a feature of EBV infectious mononucleosis.

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