What is the role of fatigue in the diagnosis of Epstein-Barr virus (EBV) infectious mononucleosis (mono)?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Profound initial fatigue and malaise is a feature of EBV infectious mononucleosis. Fatigue has extensive differential diagnoses because many systemic disorders are accompanied by fatigue. The cause of fatigue in the patient with EBV infectious mononucleosis is suggested by the constellation of signs, symptoms, and laboratory abnormalities that suggest the diagnosis. In the absence of such findings, other causes of fatigue should be sought.

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