What does a maculopapular rash contribute to the clinical picture in the diagnosis of Epstein-Barr virus (EBV) infectious mononucleosis (mono)?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Maculopapular rash may be caused by a large variety of infectious and noninfectious agents. Maculopapular rashes associated with pruritus are not caused by infectious agents. Nonpruritic maculopapular rashes may be caused by a wide variety of infectious and noninfectious disorders. The differential diagnoses of rash and fever depend largely on the distribution of the rash. Unfortunately, maculopapular rashes are generalized, offering little opportunity to narrow differential diagnostic possibilities. Therefore, the best approach to the differential diagnoses of maculopapular rashes must depend on their clinical behavior, rate of progression and/or recession, and associated nondermatologic features.

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