How is anicteric hepatitis differentiated from Epstein-Barr virus (EBV) infectious mononucleosis (mono) in elderly patients?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Patients with anicteric hepatitis present with anorexia, malaise, and fatigue. Pharyngitis may occur, but it is mild and nonexudative. Generalized adenopathy and splenomegaly may occur with anicteric hepatitis, but this occurs much more infrequently than with EBV infectious mononucleosis. Anicteric hepatitis is most likely to be confused with EBV infectious mononucleosis in elderly individuals who present with hepatitis. Positive findings on hepatitis serology and negative findings on heterophile/EBV serology differentiate these two infectious diseases.

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