What is the presentation of Epstein-Barr virus (EBV) infectious mononucleosis (mono) in patients with HIV infection?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Patients with HIV infection with acute seroconversion may present with a mononucleosislike illness with a maculopapular rash, mild pharyngitis, and lymphadenopathy. The adenopathy in HIV may be localized or generalized, but splenomegaly is not a feature of uncomplicated early HIV infection. Adenopathy localized to a lymph node group in a patient with HIV infection should suggest a lymphoma rather than a primary manifestation of acute HIV infection.

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