Which signs and symptoms differentiate rubella from Epstein-Barr virus (EBV) infectious mononucleosis (mono)?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Some of the causes of heterophile-negative infectious mononucleosis may manifest as bilateral posterior cervical adenopathy (eg, rubella), but other signs and symptoms serve to differentiate these patients from those with EBV infectious mononucleosis. Patients with rubella have other associated findings, including the distribution and progression of the rash and occipital or preauricular adenopathy; usually, they do not have generalized adenopathy, and liver involvement is not a feature of rubella infections.


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