What does uvular edema indicate in Epstein-Barr virus (EBV) infectious mononucleosis (mono)?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Uvular edema is an important and fairly specific finding in individuals with EBV infectious mononucleosis. The causes of heterophile-negative infectious mononucleosis and group A streptococcal pharyngitis are not accompanied by uvular edema. Although uncommon, uvular edema has important diagnostic significance when present. Patients with a C1q deficiency may present with uvular edema; however, these patients have no evidence of pharyngitis, fever, or adenopathy and should not be confused with patients with EBV infectious mononucleosis.

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