Which symptoms are associated with Epstein-Barr virus (EBV) infectious mononucleosis (mono)?

Updated: Sep 20, 2018
  • Author: Burke A Cunha, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Fever is usually present and is low grade, but chills are relatively uncommon. Arthralgias and myalgias occur but are less common than in other viral infectious diseases.

Nausea and anorexia, without vomiting, are common symptoms.

Various other symptoms have been described in patients with EBV infectious mononucleosis, including cough, ocular muscle pain, chest pain, and photophobia.

Importantly, patients without CNS involvement experience no cognitive difficulties. CMV infectious mononucleosis rarely involves the CNS.

Myalgias, which are uncommon, are rarely (if ever) severe.

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