What is included in the treatment of rabies prior to onset of symptoms?

Updated: Jun 21, 2019
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Before the onset of rabies symptoms, optimal results require immediate, vigorous wound cleansing; passive immunization with immunoglobulin; and active immunization with rabies vaccine. [19] Children are prone to extensive wounds on the face, upper body, and hands because of their short stature. [39] These wounds may require extensive debridement and inpatient management.

Do not administer immunoglobulin and vaccine with the same syringe or in the same site. Do not administer vaccine in the gluteus, as antibody response may be reduced.

Passive immunoglobulin provides protection for 1-2 weeks until the vaccine elicits protective antibody.

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