Which medications in the drug class Skeletal Muscle Relaxants are used in the treatment of Spasticity?

Updated: Jun 28, 2019
  • Author: Krupa Pandey, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Skeletal Muscle Relaxants

These agents may be helpful in the treatment of reversible and intractable spasticity

Dantrolene sodium (Dantrium, Revonto, Ryanodex)

This is a peripherally acting medication that prevents calcium release from the sarcoplasmic reticulum. It is particularly effective in cerebral-origin spasticity, such as that occurring in traumatic brain injury (TBI), stroke, or cerebral palsy.

Baclofen (Lioresal, Gablofen)

Baclofen presynaptically inhibits the nerve terminal. It is centrally acting and can be administered intrathecally or orally. Baclofen is the preferred drug for spasticity related to spinal cord injury (SCI) or multiple sclerosis (MS) and is useful in cerebral palsy. Tolerance can occur. Adverse effects are minimized if the drug is given intrathecally.

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