Which medications in the drug class Alpha2-adrenergic Agonists are used in the treatment of Spasticity?

Updated: Jun 28, 2019
  • Author: Krupa Pandey, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Alpha2-adrenergic Agonists

These agents may reduce sympathetic outflow from the central nervous system (CNS).

Clonidine (Catapres, Kapvay)

Clonidine stimulates alpha-2 adrenoreceptors in the brainstem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow. These effects cause a decrease in vasomotor tone and heart rate. Clonidine is effective in SCI-associated spasticity and possibly in TBI-associated spasticity as well.

Tizanidine (Zanaflex)

Tizanidine is a centrally acting muscle relaxant that is metabolized in the liver and excreted in urine and feces. It is used in patients with predominantly upper motor neuron involvement. It is not a DEA-controlled substance.

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