What is the efficacy of BoNT-B in the treatment of spasticity?

Updated: Jun 28, 2019
  • Author: Krupa Pandey, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Schwerin et al reported the following results of a pilot study in which 29 children with spasticity underwent 62 treatment sessions with BoNT-B:

  • Motor function improvement goals were attained or surpassed in 28 of 46 sessions and partially attained in 12

  • Care, hygiene, or orthotic management goals were attained in 5 of 12 sessions and partially attained in 6

  • Correction of limb position goals were attained in 3 of 4 sessions

  • Of 17 BoNT-A nonresponders, 11 attained therapy goals with BoNT-B

Side effects included dry mouth (9.7% of sessions), diarrhea (6.5%), and swallowing difficulties (6.5%). Systemic side effects were more likely when the dose surpassed 400 U/kg. The authors recommended a starting dose of BoNT-B not to exceed 400 U/kg for children up to 25 kg and a total dose for older children and adults of not more than 10,000 U. [40]

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