Which medications in the drug class Corticosteroids are used in the treatment of Leptospirosis?

Updated: Jul 08, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Corticosteroids

In patients with leptospirosis, corticosteroids are indicated to improve renal failure outcome.

Methylprednisolone (A-Methapred, Medrol, Depo-Medrol, Solu-Medrol)

Methylprednisolone decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. High-dose pulsed methylprednisolone (30 mg/kg/d, not to exceed 1500 mg) has been used successfully to treat patients with leptospiral renal failure without dialysis.


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