What is the role of CSF analysis in the diagnosis of leptospirosis?

Updated: Jul 08, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Analysis of the CSF is useful only in excluding other causes of bacterial meningitis. When the CNS becomes involved in leptospirosis, polymorphonuclear leukocytes initially predominate and are later replaced by monocytes. CSF protein may be normal or elevated, whereas glucose levels remain normal. CSF pressure is normal, but a lumbar puncture can relieve the headache. Leptospires are routinely isolated from the CSF, but this finding does not change management of the disease.

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