What are the US Health Resources and Services Administration (HRSA) recommended treatment regimens for leprosy?

Updated: Aug 24, 2018
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

US regimens emphasize the use of rifampin, which is the most bactericidal drug used to treat leprosy.

Table 2. US Recommendations for Multidrug Therapy [15] (Open Table in a new window)

Type of Leprosy Daily, Self-Administered Monthly Supervised Months of Treatment
Paucibacillary

Dapsone 100 mg,

Rifampicin 600 mg

N/A 12
Single-lesion paucibacillary

Dapsone 100 mg,

Rifampicin 600 mg

N/A 12
Multibacillary

Dapsone 100 mg,

Rifampicin 600 mg,

Clofazimine 50 mg

N/A 24

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