Which medications in the drug class Xanthine Oxidase Inhibitors are used in the treatment of Leishmaniasis?

Updated: Feb 18, 2020
  • Author: Craig G Stark, MD, FACP, FFTM, RCPS(Glasg), FISTM; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Xanthine Oxidase Inhibitors

Xanthine oxidase inhibitors may be added to first-line drugs for treatment against protozoal infections.

Allopurinol (Zyloprim, Aloprim)

Allopurinol inhibits xanthine oxidase, the enzyme that synthesizes uric acid from hypoxanthine. This reduces the synthesis of uric acid without disrupting the biosynthesis of vital purines.

Allopurinol is not effective as monotherapy for leishmaniasis.


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