What is the role of antiparasitic pentavalent antimonials in the treatment of leishmaniasis?

Updated: Feb 18, 2020
  • Author: Craig G Stark, MD, FACP, FFTM, RCPS(Glasg), FISTM; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Antiparasitic pentavalent antimonials, such as sodium stibogluconate (Pentostam) or meglumine antimonate, have been the mainstays of therapy for all forms of the disease. [57] Until recently, sodium stibogluconate was the drug of choice in most areas and the only recommended treatment in the United States, but resistance is rising.

Pentavalent antimony is not marketed in the United States, but it can be obtained through the Centers for Disease Control and Prevention (CDC) Drug Service (404-639-3670), under an Investigational New Drug (IND) approved by the Food and Drug Administration (FDA), and by the CDC’S Institutional Review Board (IRB). [2]


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