What are the signs and symptoms of Klebsiella chronic genital ulcerative disease?

Updated: Jun 10, 2019
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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K granulomatis infection can result in granuloma inguinale or donovanosis, although these are uncommon in developed temperate countries. The mode of transmission is uncertain but is believed to be sexually transmitted. The incubation period is 1-3 weeks.

Ulcerative infection is likely transmitted by contact with microabraded skin. Nonulcerative infection is probably transmitted transepithelially.

Coinfection with other sexually transmitted diseases (STDs) is common.

Klebsiella chronic genital ulcerative disease presents as a firm papule or subcutaneous nodule that later ulcerates. An ulcerogranulomatous presentation is most common and is characterized as a beefy red ulcer. A hypertrophic or verrucous presentation may mimic condylomata acuminate. A necrotic presentation is characterized by a deep ulcer. Sclerotic and cicatricial presentations are rare.

Diagnosis is based on clinical suspicion. Direct microscopy shows intracytoplasmic bipolar staining inclusion bodies (Donovan bodies).

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