Which medications in the drug class Uricosuric Agents are used in the treatment of Influenza?

Updated: Apr 23, 2019
  • Author: Hien H Nguyen, MD, MS; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Uricosuric Agents

Agents that inhibit the tubular secretion of the active metabolite of oseltamivir may be used as adjunctive therapy with this antiviral drug.

Probenecid

Probenecid inhibits tubular secretion of the active metabolite of oseltamivir, reducing its clearance by approximately 50% and approximately doubling systemic exposure to oseltamivir. The appropriate dosing for combination therapy with probenecid and oseltamivir in the treatment of avian influenza has not been established.


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