What are the CDC influenza vaccination guidelines?

Updated: Aug 07, 2020
  • Author: Hien H Nguyen, MD, MS; Chief Editor: Michael Stuart Bronze, MD  more...
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Routine annual influenza vaccination is recommended for all persons aged 6 months or older who do not have contraindications. A licensed, recommended, and age-appropriate vaccine should be used. [93, 94]

Inactivated influenza vaccines (IIVs) are available in trivalent (IIV3) and quadrivalent (IIV4) formulations. Recombinant influenza vaccine (RIV) is available in trivalent (RIV3) and quadrivalent (RIV4) formulations.

Live attenuated influenza vaccine (LAIV4; FluMist Quadrivalent) was not recommended for use during the 2017-2018 influenza season owing to concerns about its effectiveness against (H1N1)pdm09 viruses during the 2013-2014 and 2015-2016 seasons. The ACIP has recommended return of LAIV4 in the United States for the 2018-2019 season based on positive results from a US study in children aged 2 years to younger than 4 years that evaluated the shedding and antibody responses of the H1N1 strain following LAIV4 administration. [95]

Vaccine viruses included in the 2019-2020 US trivalent influenza vaccines contain the following components:

  • A/Brisbane/02/2018 (H1N1)pdm09-like virus (new for 2019-2020)
  • A/Kansas/14/2017 (H3N2)-like virus (new for 2019-2020)
  • B/Colorado/06/2017-like virus (B/Victoria/2/87 lineage) (no change from preceding season)

Quadrivalent influenza vaccines will contain these 3 viruses and an additional influenza B vaccine virus, a B/Phuket/3073/2013–like virus (Yamagata lineage) (no change from the preceding season).

Pregnant women may receive any licensed, recommended, age-appropriate influenza vaccine.

Afluria (IIV3; Seqirus, Parkville, Victoria, Australia) may be used for persons aged 5 years or older, consistent with FDA-approved labeling.

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