What vaccine is FDA approved for prevention of avian influenza (H5N1)?

Updated: Aug 07, 2020
  • Author: Hien H Nguyen, MD, MS; Chief Editor: Michael Stuart Bronze, MD  more...
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In November 2013, the FDA approved the first adjuvanted vaccine for the prevention of H5N1 avian influenza. Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted (ID Biomedical Corporation), is meant for use in people aged 18 years or older with a relatively greater risk of H5N1 exposure. It is not intended for commercial use but has instead been purchased by the US Department of Health and Human Services for addition to the Strategic National Stockpile (of drugs and medical supplies) and, if warranted, subsequent distribution by public health officials. [70, 71]

Approval of the vaccine was based on a multicenter study in which investigators evaluated the immune response of about 2000 vaccinated adults, determining that 91% of persons aged 18-64 years and 74% of those aged 65 years or older achieved an antibody level that would be expected to reduce their risk of developing avian influenza. [70, 71]

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