Which complications can occur in the clinical course of avian influenza (H5N1)?

Updated: Aug 07, 2020
  • Author: Hien H Nguyen, MD, MS; Chief Editor: Michael Stuart Bronze, MD  more...
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A review of avian influenza cases in 4 countries found that the clinical course progressed to ARDS and respiratory failure in 70-100% of patients. [31] The mean time to the development of ARDS was 6 days. Lymphopenia at presentation is a significant predictor of the progression to ARDS and death. [32]

Severe cases of avian influenza may progress to multiorgan failure. In a study of 12 hospitalized patients with confirmed H5N1 influenza, 75% had respiratory failure, 42% had cardiac failure, and 33% had renal failure. [31]

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