What is the role of 5-fluorouracil (FU) in the treatment of human papillomavirus (HPV)?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Another option is 5-FU cream, which interferes with DNA and RNA synthesis, thereby creating a thymine deficiency that resulting in unbalanced cellular growth and cell death. Limited data exist concerning the efficacy of this therapy for genital warts. Three case series indicated wart clearance in 10-50% of participants. [80] A meta-analysis of 6 trials involving 645 women concluded that topical treatment with 5-FU has a therapeutic effect; the data were unclear on the risks and benefits, and further studies were recommended. [81]

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