How is podophyllin administered in the treatment of human papillomavirus (HPV)?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1 treatment. Before application, thoroughly cleanse the affected area. Avoid contact with healthy tissue. Apply the medicine sparingly, and allow it to dry thoroughly. The initial application should be for 30-40 minutes; subsequent applications can be for 1-4 hours. Remove dried podophyllin with alcohol or with soap and water. Do not treat large areas or numerous warts at once.

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