How is interferon alfa used in the treatment of human papillomavirus (HPV)?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Interferon alfa is used for intralesional treatment of external anogenital warts and condyloma acuminatum. It is injected into the base of each wart, preferably via a 30-gauge needle, in a dosage of 3 million IU 3 times per week for 3 weeks. For large warts, it may be injected at several points around the periphery in a total dose of 250,000 IU per wart. Direct the needle at the center of the base of the wart and at an angle almost parallel to the plane of the skin (approximating the angle used in the commonly used purified protein derivative [PPD] test).

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