What is the role of histopathology in the diagnosis of human papillomavirus (HPV) infection?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Histopathology can elucidate the diagnosis in most cases. Verrucae consist of acanthotic epidermis with papillomatosis, hyperkeratosis, and parakeratosis. Elongated rete ridges may point to the center of the wart, and dermal capillary vessels may be thrombosed. An electron microscope may show viral particles in nuclei. Immunohistochemical staining with the peroxidase-antiperoxidase technique stains cells infected by viral particles.

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