What is the role of self-collected vaginal human papillomavirus (HPV) specimens in the surveillance of cervical intraepithelial neoplasia (CIN)?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

A trial comparing more than 12,000 women who self-collected vaginal HPV specimens with a similar number who underwent cervical cytology screening found that whereas self-collected HPV had a positive predictive value of only 12%, it was 3.4 times more sensitive for detecting CIN II than cervical cytology was and detected 4.2 times more invasive cervical cancers. [62] These findings suggest that self-collected vaginal HPV testing might be a viable surveillance option in communities where cytology screening programs are limited by resources.


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