What are the complications of human papillomavirus (HPV) disease?

Updated: Feb 20, 2020
  • Author: Peter A Gearhart, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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However, disease complications can include progression to malignancy and transmission to other sexual contacts. In the setting of genital warts active during a pregnancy delivery, there is a small risk of laryngeal papillomatosis. Whereas the vast majority of genital HPV infections resolve spontaneously, persistent infection can lead to neoplastic changes. Cervical cancer is the second most common cause of morbidity and death in women in the United States. Malignancies such as Bowen tumors may also lead to morbidity and death.

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