Which medications in the drug class Antibiotics are used in the treatment of Tenosynovitis?

Updated: Oct 25, 2017
  • Author: Mark R Foster, MD, PhD, FACS; Chief Editor: Harris Gellman, MD  more...
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Answer

Antibiotics

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Ceftriaxone (Rocephin)

Ceftriaxone is a third-generation cephalosporin that has a broad gram-negative spectrum, lower efficacy against gram-positive organisms, and higher efficacy against resistant organisms. By binding to 1 or more of the penicillin-binding proteins, it arrests bacterial cell wall synthesis and inhibits bacterial growth. Ceftriaxone is used because of an increasing prevalence of penicillinase-producing N gonorrhoeae.

Ciprofloxacin (Cipro)

This is a bactericidal antibiotic that inhibits bacterial DNA synthesis and (consequently) growth by inhibiting DNA-gyrase in susceptible organisms. The duration of treatment depends on the severity of the infection.

Ampicillin and sulbactam (Unasyn)

This drug combination uses a beta-lactamase inhibitor with ampicillin; it covers skin, enteric flora, and anaerobes. Ampicillin/sulbactam is used for the treatment of nongonococcal infectious tenosynovitis. Its coverage includes Staphylococcus and Streptococcus species, as well as anaerobes.

Cefazolin

Cefazolin is a first-generation, semisynthetic cephalosporin that, by binding to 1 or more of the penicillin-binding proteins, arrests bacterial cell wall synthesis and inhibits bacterial growth. It is active primarily against skin flora, including Staphylococcus aureus. It is typically used alone for skin and skin-structure coverage. Cefazolin is administered for the treatment of suspected staphylococcal and/or streptococcal tenosynovitis (anaerobes not suspected).


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