Which medications are used in the treatment of tenosynovitis?

Updated: Nov 22, 2019
  • Author: Mark R Foster, MD, PhD, FACS; Chief Editor: Harris Gellman, MD  more...
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The goals of tenosynovitis therapy are to reduce pain and eradicate infection. Initial treatment for suspected infectious FT may include IV antibiotics if the patient presents very early.

In inflammatory FT resulting from an overuse syndrome, NSAIDs can be administered if tolerated by the patient. Flexor tendon sheath or carpal tunnel corticosteroid injections can be administered to decrease pain and the inflammatory response. However, corticosteroid injections should be used with caution, as they are detrimental if injected directly into the tendon or ligament. Multiple injections also can weaken the tendon and lead to rupture in patients with diabetes or inflammatory arthritis.

Pharmacologic treatment for rheumatoid inflammatory FT includes NSAIDs, hydroxychloroquine, gold, penicillamine, and methotrexate. Persistent cases may require oral steroid treatment. For acute flares of FT in patients with rheumatoid arthritis, corticosteroid injections may provide prompt relief.

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