What are the treatment options for recurrent herpes simplex virus (HSV) infections?

Updated: Mar 01, 2018
  • Author: Folusakin O Ayoade, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Options for recurrent HSV infections include no treatment (for infrequent episodes) or episodic treatment with topical agents or oral antiviral agents. Long-term suppressive therapy, which can be continued for up to one year, is also an option. A modest benefit with lower recurrences has been reported using this method. [21, 22]

The best approach is to determine the frequency and severity of recurrent infections and the patient's preference concerning prophylaxis. Options for long-term suppressive therapy include acyclovir 400 mg orally twice daily or valacyclovir 500 mg orally twice daily for up to a year, with reassessment at the end of therapy.

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