Which medications in the drug class Antidiabetics, Insulins are used in the treatment of Calcium Channel Blocker Toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Antidiabetics, Insulins

Case reports of patients treated with high-dose insulin are beginning to support the use of this drug in calcium channel blocker toxicity. Insulin increases cardiac output and may increase survival as long as plasma glucose levels are monitored and supplemented with exogenous dextrose. To date, no prospective human trials have been published supporting this practice.

Insulin regular (Humulin R, Novolin R)

Calcium channel blockers inhibit the production of islet cells and the secretion of insulin and block free fatty acid uptake by the heart muscle. High-dose insulin may augment myocyte uptake of glucose during times of stress induced by calcium channel blocker overdose. Insulin's action provides additional metabolic support to improve cardiac contractility.


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