What is the role of 4-aminopyridine and 3.4 diaminopyridine in the treatment of calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

4-Aminopyridine and 3,4-diaminopyridine increase calcium entry into the cell. Their exact mechanism is not fully understood, but they may indirectly promote calcium entry by blocking voltage-sensitive potassium channels. Although these medications have reversed verapamil toxicity in feline, canine, and rabbit experiments, their value and safety in human calcium channel blocker toxicity has not been established. It cannot be recommended at this time for CCB toxicity.


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