How is lipid emulsion therapy administered in the treatment of calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Lipid emulsion 20% should be given IV in the following dose regimen:

  • Lipid emulsion 20%: 1.5 mL/kg over 1 minute
  • Follow immediately with an infusion at a rate of 0.25 mL/kg/min
  • Continue chest compressions if patient is receiving cardiopulmonary resuscitation (CPR) (lipid must circulate)
  • Repeat bolus every 3-5 minutes, up to 3 mL/kg total dose, until circulation is restored
  • Continue infusion until hemodynamic stability is restored; increase the rate to 0.5 mL/kg/min if blood pressure declines
  • Maximum total dose of 8 mL/kg is recommended

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