Which conditions are included in the differential diagnoses of calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

The conditions listed below should be considered in the differential diagnosis of calcium channel blocker (CCB) toxicity.

The following are the main common toxicity-causing agents:

  • Ingestion of beta-blocking agents
  • Acute or chronic digoxin toxicity
  • Ingestion of clonidine or other central alpha-2 agonists
  • Ingestion of any plants containing digoxin-like compounds or other cardiotoxins (eg, grayanotoxin, oleander, foxglove)
  • Opioid toxicity
  • Ingestion of any sedative-hypnotics, including benzodiazepines, barbiturates, and nonbarbiturate sedative-hypnotics

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