What is the pathogenesis of nisoldipine toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Nisoldipine (Sular), a dihydropyridine, is highly metabolized, which results in only 1 active metabolite that has about 10% the activity of the parent compound. Nisoldipine elicits predominantly peripheral hemodynamic effects. It decreases systemic vascular resistance and blood pressure. It has a relatively high affinity for the calcium channels in the smooth muscle cells of vascular tissue and causes little to no AV nodal interference.


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