What is the pathogenesis of nicardipine and nimodipine toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Nicardipine (Cardene, Cardene SR) and nimodipine (Nimotop) are similar to nifedipine, although they demonstrate greater peripheral vascular smooth muscle effects. They may have small, negative inotropic effects. Nicardipine and nimodipine are predominantly metabolized by the liver. They do not exhibit a large first-pass effect, as is observed with other CCBs. Nimodipine has selectivity for the cerebral vasculature because of its high lipid solubility and ability to cross the blood-brain barrier; it has been approved for use in the treatment of cerebral ischemia after subarachnoid hemorrhage. Nicardipine is also available as an IV formulation for the control of hypertension.


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