What is the pathogenesis of diltiazem toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Teczem, Tiazac) demonstrates an affinity for cardiac conductive tissues and vascular smooth muscle cells, but its clinical response more closely resembles that of verapamil than of nifedipine. Diltiazem mainly undergoes hepatic metabolism, with a large first-pass effect that may differ from patient to patient.


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