What are the pharmacokinetics of calcium channel blockers (CCBs)?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

The pharmacokinetics of CCBs are as follows:

  • Amlodipine (Norvasc): Peak plasma level, 6-9 hours; half-life, 30-50 hours
  • Bepridil (Vascor): Peak plasma level, 2-3 hours; half-life, 24 hours
  • Diltiazem immediate release (IR) (Cardizem): Peak plasma level, 2-4 hours; half-life, 3.5-6 hours
  • Diltiazem sustained-release (SR) (Cardizem SR): Peak plasma level, 6-11 hours; half-life, 5-7 hours
  • Diltiazem controlled delivery (Cardizem CD): Peak plasma level, 10-14 hours; half-life, 5-8 hours
  • Diltiazem extended-release (XR or XT) (Dilacor): Peak plasma level, 4-6 hours; half-life, 5-10 hours
  • Felodipine (Plendil): Peak plasma level, 2.5-5 hours; half-life, 11-16 hours
  • Isradipine (DynaCirc): Peak plasma level, 0.5-2 hours; half-life, 8 hours
  • Nicardipine (Cardene): Peak plasma level, 0.5-2 hours; half-life, 2-4 hours
  • Nifedipine immediate release (IR) (Procardia): Peak plasma level, 0.5 hour; half-life, 2-5 hours
  • Nifedipine extended-release (XL) (Procardia XL): Peak plasma level, 7-10 hours; half-life, 7 hours
  • Nimodipine (Nimotop): Peak plasma level, less than 1 hour; half-life, 1-2 hours
  • Nisoldipine (Sular): Peak plasma level, less than 6-12 hours; half-life, 7-12 hours
  • Verapamil immediate release (IR) (Calan Isoptin): Peak plasma level, less than 1-2 hours; half-life, 3-7 hours
  • Verapamil sustained-release (Calan SR, Isoptin SR, Verelan): Peak plasma level, less than 5-11 hours; half-life, 12 hours

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