What causes calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
  • Print

The toxic potential of calcium channel blockers (CCBs) varies with the formulation (eg, immediate-release or sustained-release) and the pharmacologic subclass. The CCBs have a certain degree of tissue specificity, but the drugs do have common properties. CCBs are all well absorbed in the gastrointestinal (GI) system, although diltiazem has extensive first-pass metabolism. The CCBs are substantially bound by plasma proteins and are predominantly metabolized by the liver. Therefore, impaired renal function should not alter CCB metabolism.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!