What are the cardiovascular effects of calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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Answer

Calcium channel blockers have the following four cardiovascular effects:

  • Peripheral arterial vasodilatation
  • Negative chronotropy (decreased heart rate through sinoatrial node inhibition)
  • Negative dromotropy (decreased cardiac conduction through atrioventricular node inhibition)
  • Negative inotropy (decreased cardiac contractility)

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