How is high-dose insulin euglycemia (HIE) administered in the treatment of calcium channel blocker (CCB) toxicity?

Updated: Jan 04, 2021
  • Author: B Zane Horowitz, MD, FACMT; Chief Editor: Michael A Miller, MD  more...
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High-dose insulin therapy is administered as follows:

  • Infuse one ampule of D50W
  • Give an insulin bolus of 1 U/kg, followed by an infusion of 1-10 U/kg/h
  • Monitor serum potassium and glucose levels every 20-30 minutes
  • D5W infusions usually suffice to maintain glucose levels

See Treatment and Medication for more detail.

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