What is the role of osteocalcin monitoring in the prevention of hypercalciuria?

Updated: Jun 02, 2021
  • Author: Stephen W Leslie, MD, FACS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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An intriguing suggestion has been made that osteocalcin levels be used before and after dietary calcium restriction. [58] Osteocalcin is released during periods of bone resorption, which would be expected with renal leak hypercalciuria, hyperparathyroidism, or any dietary calcium ̶ resistant hypercalciuria. Patients with elevated osteocalcin levels theoretically would benefit from thiazide and/or bisphosphonate therapy to prevent bone demineralization over time, even if their hypercalciuria is well controlled with dietary therapy alone. Estrogen can be added in women.

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