What is the role of serum studies in the workup of hypercalciuria?

Updated: Jun 02, 2021
  • Author: Stephen W Leslie, MD, FACS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Ideally, serum laboratory studies should be drawn at the same time that the 24-hour urine sample is being collected. In this way, the action of the kidneys can be viewed in the context of serum levels of these same parameters.

Minimum blood tests currently recommended for stone formers include the following:

  • Calcium
  • Phosphorus
  • Electrolytes
  • Uric acid
  • Creatinine

Serum calcium studies should be repeated when initial levels are high, along with PTH levels to check for hyperparathyroidism. Serum intact PTH and ionized calcium are the most reliable in borderline cases. (Vitamin D and vitamin D3 levels are available in some laboratories and, although useful in select cases, are still considered investigational.)

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